im running nl in the same way(24/24 7/7), there are no troubles but the 3 cases i listed in the previous post + 1 i just noticed while downloading a torrent folder with a lot of miedum/small files, with ed2k global option share automatically on, core got unstable (massively - i couldnt even change settings in the meanwhile) i checked stats and ed2k was firewalled. i had to restart to fix.
and after restarting i just disabled ed2k auto share and keeping downloading those kind of torrents with no problems.
btw the question 24/24 was meant for OwenB. sorry, i'll try to be more precise next time.
@DavidX is it possible to disable neoshare autoshare, like i did with ed2k?